News Release

RCMG Inc. is pleased to announce that the fist paper for HBsAgGi, entitled “O-Glycosylated HBsAg peptide can induce specific antibody neutralizing HBV infection” were published in Biochimica et Biophysica Acta - General Subjects (https://pubmed.ncbi.nlm.nih.gov/34582939/) under research collaboration with National Institute of Advanced Industrial Science and Technology (AIST).

Our research team previously found that the specific glycan structure on HB surface antigen that predominantly expressed by DNA virion-containing viral particle. This time, we successfully established the new monoclonal antibody against the specific structure and demonstrated that the antibody strongly blocked HBV infection to human hepatocytes in vitro compared with clinical available HBIG (Human anti-HBs ImmunoGlobulin).

HBsAgGi (HB surface antigen glycan isomer) is a monoclonal antibody specific to O-glycosylated Pre-S2 on M-HBs, which is the specific glycan structure described above. HBsAgGi is now available for research use only and can be purchased from RCMG Inc. More detail information is available at our PROJECT and PRODUCTS page. 

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Research results in which Drs. Narimatsu (former CEO) and Angata (CEO) of our company participated were published in the journal “Oncology Letters.”
Boottanun P, Ino Y, Shimada K, Hiraoka N, Angata K, Narimatsu H. Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma. Oncol Lett. 2021 22(5):760. doi: 10.3892/ol.2021.13021. 

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Research results in which Dr. Narimatsu (CEO) and Sogabe (Researcher) of our company participated were published in the journal “Glycobiology.”
Noro E, Matsuda A, Kyoutou T, Sato T, Tomioka A, Nagai M, Sogabe M, Tsuruno C, Takahama Y, Kuno A, Tanaka Y, Kaji H, Narimatsu H. N-glycan structures of Wisteria floribunda agglutinin-positive Mac2 binding protein in the serum of patients with liver fibrosis. Glycobiology. 2021 cwab060. doi: 10.1093/glycob/cwab060. 

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RCMG has appointed Dr. Kiyohiko Angata as Chief Executive Officer. Dr. Narimatsu, previous CEO of RCMG, has been appointed as Chairman of the Board.

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the journal “Journal of Proteome Research.”
Nagai-Okatani C, Zou X, Fujita N, Sogabe I, Arakawa K, Nagai M, Angata K, Zhang Y, Aoki-Kinoshita KF, Kuno A. LM-GlycomeAtlas Ver. 2.0: An Integrated Visualization for Lectin Microarray-based Mouse Tissue Glycome Mapping Data with Lectin Histochemistry. J Proteome Res. 2021 20(4):2069-2075. doi: 10.1021/acs.jproteome.0c00907.

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Research results in which Dr. Angata (Head of R&D) of our company participated were presented in the conference “HUPO Connect 2020.”
Nagai-Okatani C, Zou X, Fujita N, Sogabe I, Arakawa K, Nagai M, Angata K, Zhang Y, Aoki-Kinoshita KF, Kuno A. Update on LM-GlycomeAtlas: An integrated visualization for mouse tissue glycome mapping data with lectin histochemistry. The 19th Human Proteome Organization World Congress via WEB on 0ctober 19-20, 2020. 

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Research results in which Dr. Angata (Head of R&D) of our company participated were presented in the conference “HUPO Connect 2020.”
Nagai-Okatani C, Zou X, Fujita N, Sogabe I, Arakawa K, Nagai M, Angata K, Zhang Y, Aoki-Kinoshita KF, Kuno A. Update on LM-GlycomeAtlas: An integrated visualization for mouse tissue glycome mapping data with lectin histochemistry. The 19th Human Proteome Organization World Congress via WEB on 0ctober 19-20, 2020. 

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Dr. Hisashi Narimatsu (CEO) of our company received ‘Dr. Kohzoh Imai Award’ at The 40th Annual Meeting of the Japan Society for Molecular Tumor Marker Research held at Hiroshima and WEB on September 30th, 2020. 

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Research results in which Drs. Narimatsu (CEO) and Angata (Head of R&D) of our company participated were published in the journal “Hepatology Research.”
This study demonstrated for the first time that glycogene would be a novel therapeutic target for HBV infection by regulating HBsAg and DNA secretion from hepatocytes.
Ito K, Angata K, Kuno A, Okumura A, Sakamoto K, Inoue R, Morita N, Watashi K, Wakita T, Tanaka Y, Sugiyama M, Mizokami M, Yoneda M, Narimatsu H. Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus. Hepatol Res. 2020 50(10):1128-1140. doi: 10.1111/hepr.13552. 

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Research results in which Drs. Narimatsu (CEO) and Angata (Head of R&D) of our company participated were published in the journal “Frontiers in Oncology.”
This study comprehensively evaluated the glycogene profile in human HCC cell lines through novel RNA-seq/qPCR methodology and showed the advantage of glycoprotein-based biomarker compared to traditional protein-based biomarker.
Angata K, Sawaki H, Tsujikawa S, Ocho M, Togayachi A, Narimatsu H.
Glycogene Expression Profiling of Hepatic Cells by RNA-Seq Analysis for Glyco-Biomarker Identification. Front Oncol. 2020 10:1224. doi: 10.3389/fonc.2020.01224. 

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Research results in which Drs. Narimatsu (CEO) and Angata (Head of R&D) of our company participated were published in the journal “Clinica Chimica Acta.”
Silsirivanit A, Matsuda A, Kuno A, Tsuruno C, Uenoyama Y, Seubwai W, Angata K, Teeravirote K, Wongkham C, Araki N, Takahama Y, Wongkham S, Narimatsu H. Multi-serum glycobiomarkers improves the diagnosis and prognostic prediction of cholangiocarcinoma. Clin Chim Acta. 2020 510:142-149. doi: 10.1016/j.cca.2020.07.017. 

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Research results in which Drs. Narimatsu (CEO) and Angata (Head of R&D) of our company participated were published in the journal “Nature Methods.”
Yamada I, Shiota M, Shinmachi D, Ono T, Tsuchiya S, Hosoda M, Fujita A, Aoki NP, Watanabe Y, Fujita N, Angata K, Kaji H, Narimatsu H, Okuda S, Aoki-Kinoshita KF. The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences. Nat Methods. 2020 17(7):649-650. doi: 10.1038/s41592-020-0879-8. 

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AIST and RCMG Inc. signed an exclusive licensing agreement under which RCMG Inc. will receive an exclusive license to develop and commercialize diagnostics for non-small cell lung cancer (NSCLC). 

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Research results in which Dr. Narimatsu (CEO) of our company participated were published in the journal, “Journal of Proteome Research.”
Matsuda A, Kuno A, Yoshida M, Wagatsuma T, Sato T, Miyagishi M, Zhao J, Suematsu M, Kabe Y, Narimatsu H. Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines. J Proteome Res. 2020 19(6):2516-2524. doi: 10.1021/acs.jproteome.0c00200. 

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AIST and RCMG Inc. signed an exclusive licensing agreement under which RCMG Inc. will receive an exclusive license to develop and commercialize diagnostics for small cell lung cancer (SCLC). 

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AIST and RCMG Inc. signed an exclusive licensing agreement under which RCMG Inc. will receive an exclusive license to develop and commercialize HBV diagnostics worldwide. 

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Research results in which Dr. Angata (Head of R&D) of our company participated were published in the journal “Molecules.”
Nagai-Okatani C, Aoki-Kinoshita KF, Kakuda S, Nagai M, Hagiwara K, Kiyohara K, Fujita N, Suzuki Y, Sato T, Angata K, Kuno A. LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections. Molecules. 2019 24(16):2962. doi: 10.3390/molecules24162962. 

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Dr. Narimatsu (CEO) of our company presented as a speaker at the international conference held at University of Milano in Italy.
Narimatsu H. Development of liver fibrosis diagnostics, M2BPGi, using glycoscience technologies. The 25th International Symposium on Glycoconjugate, held at Milano on August 25-31, 2019. 

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RCMG Inc. was certified as the technology transfer company by National Institute of Advanced Industrial Science and Technology. 

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Research results in which Drs. Narimatsu (CEO) and Angata (Head of R&D) of our company participated were published in the journal “Journal of Biological Chemistry.”
Nakane T, Angata K, Sato T, Kaji H, Narimatsu H. J Biol Chem. Identification of mammalian glycoproteins with type-I LacdiNAc structures synthesized by the glycosyltransferase B3GALNT2. 2019 294(18):7433-7444. doi: 10.1074/jbc.RA118.006892. 

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Research results in which Dr. Narimatsu (CEO) of our company participated were published in the journal, “Human Fertility.”
Hagiuda J, Takasaki N, Oya M, Ishikawa H, Narimatsu H. Mutation of GALNTL5 gene identified in patients diagnosed with asthenozoospermia. Hum Fertil (Camb). 2020 23(4):226-233. doi: 10.1080/14647273.2018.1562239.