RCMG Inc. is pleased to announce that the fist paper for HBsAgGi, entitled “O-Glycosylated HBsAg peptide can induce specific antibody neutralizing HBV infection” were published in Biochimica et Biophysica Acta - General Subjects (https://pubmed.ncbi.nlm.nih.gov/34582939/) under research collaboration with National Institute of Advanced Industrial Science and Technology (AIST).
Our research team previously found that the specific glycan structure on HB surface antigen that predominantly expressed by DNA virion-containing viral particle. This time, we successfully established the new monoclonal antibody against the specific structure and demonstrated that the antibody strongly blocked HBV infection to human hepatocytes in vitro compared with clinical available HBIG (Human anti-HBs ImmunoGlobulin).
HBsAgGi (HB surface antigen glycan isomer) is a monoclonal antibody specific to O-glycosylated Pre-S2 on M-HBs, which is the specific glycan structure described above. HBsAgGi is now available for research use only and can be purchased from RCMG Inc. More detail information is available at our PROJECT and PRODUCTS page.